Escitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K<sup>+</sup> channels in coronary arterial smooth muscle cells
Escitalopram, a selective serotoㅁEscitalopram, a selective serotonin reuptake inhibitor, inhibits voltage-dependent K<sup>+</sup> channels in coronary arterial smooth muscle cellsnin reuptake inhibitor, inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells
- Han Sol Kim Hongliang Li Hye Won Kim Sung Eun Shin Mi Seon Seo Jin Ryeol An Kwon-Soo Ha Eun-Taek Han
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제21권 제4호
- 등재여부 : KCI등재
- 2017.01
- 415 - 421 (7 pages)
We investigated the inhibitory effect of escitalopram, a selective serotonin reuptake inhibitor (SSRI), on voltage-dependent K<sup>+</sup> (Kv) channels in freshly separated from rabbit coronary arterial smooth muscle cells. The application of escitalopram rapidly inhibited vascular Kv channels. Kv currents were progressively inhibited by an increase in the concentrations of escitalopram, suggesting that escitalopram inhibited vascular Kv currents in a concentration-dependent manner. The IC<sub>50</sub> value and Hill coefficient for escitalopram-induced inhibition of Kv channels were 9.54±1.33 µM and 0.75±0.10, respectively. Addition of escitalopram did not alter the steady-state activation and inactivation curves, suggesting that the voltage sensors of the channels were not affected. Pretreatment with inhibitors of Kv1.5 and/or Kv2.1 did not affect the inhibitory action of escitalopram on vascular Kv channels. From these results, we concluded that escitalopram decreased the vascular Kv current in a concentration-dependent manner, independent of serotonin reuptake inhibition.