Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice
Caffeic acid phenethyl ester protects against photothrombotic cortical ischemic injury in mice
- Sun Ae Hwang Chi Dae Kim Won Suk Lee
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제22권 제1호
- 등재여부 : KCI등재
- 2018.01
- 101 - 110 (10 pages)
In this study, we aimed to investigate the neuroprotective effects of caffeic acid phenethyl ester (CAPE), an active component of propolis purified from honeybee hives, on photothrombotic cortical ischemic injury in mice. Permanent focal ischemia was achieved in the medial frontal and somatosensory cortices of anesthetized male C57BL/6 mice by irradiation of the skull with cold light laser in combination with systemic administration of rose bengal. The animals were treated with CAPE (0.5-5 mg/kg, i.p.) twice 1 and 6 h after ischemic insult. CAPE significantly reduced the infarct size as well as the expression of tumor necrosis factor-α, hypoxia-inducible factor-1α, monocyte chemoattractant protein-1, interleukin-1α, and in-doleamine 2,3-dioxygenase in the cerebral cortex ipsilateral to the photothrombosis. Moreover, it induced an increase in heme oxygenase-1 immunoreactivity and interleukin-10 expression. These results suggest that CAPE exerts a remarkable neuroprotective effect on ischemic brain injury via its anti-inflammatory properties, thereby providing a benefit to the therapy of cerebral infarction.