능이버섯(Sarcodon aspratus) 추출물의 생리활성

This study was carried out to find the preventive medical and therapeutic effects of Sarcodon asparatus on adult disease by employing several biological and biochemical assays. Nitrate scavenging ability(NSA) of Sarcodon asparatus extracts was displayed up to 99.9% at pH 1.2 in a dose-dependent manner. They also had 90.4% electron donating ability(EDA) at the concentrations(0.01~1.0 mg/mL). Furthermore, we observed that 1 mg/mL concentration of the extracts was more powerful than BHT. With respect to fibrolytic activity, effects Sarcodon asparatus showed 1,843.8 unit/g, which was higher than streptokinase(1,189 unit/g). The inhibitory effects of the extracts on angiotensin converting enzyme, measured by the normal and pretreatment methods, were 53 and 58%, respectively. We also performed cytotoxicity effect of Sarcodon asparatus extracts on a various cancer cell lines. The growth inhibitory effects fo the extracts(5.0 mg/mL) on A549, HeLa, AGS, and SK-Hep-1 cell were 78.9, 55.3, 69.0, and 42.5%, respectively. Interestingly, Sarcodon asparatusextracts induced mutation on Salmonella typhimurium TA98 and TA100 when Ames test was done.