코팅물질과 유화제가 나노입자 제조 및 안정성에 미치는 영향

The objective of this study was to investigate the influence of emulsion processing with various homogenization treatments on the physical properties of nanoparticles. For the manufacturing of nanoparticles, by taking the emulsion-diffusion method, various coating materials, such as gum arabic, hydroxyethyl starch, polycarprolactone, paraffin wax, k-carrageenan and emulsifiers like Tween？60, Tween？80, monoglyceride and Pluronic？F68, were added into the emulsion system. Furthermore, the various speeds (7,000 rpm to 10,000 rpm), and times (15 s to 60 s) of homogenization were treated during the emulsion-diffusion process. NEO II homomixer was the most effective homogenizer for making nanoparticles as 51 nm (D10) and 26 nm (D50). To manufacture smaller nanoparticles, by using NEO II homomixer, 10,000 rpm of agitation speed, polycapro-lactone as coating material, and Pluronic？F68 as an emulsifier were the optimum operating conditions and components. For the stability of nanoparticles for 7 days, 20oC of storage temperature was appropriate to maintain the particle size, from these results, the type of homogenizer, homogenization speed, homogenization time and storage temperature could affect the particle size. Moreover, type of coating materials and emulsifier also influenced the size and stability of the nanoparticles.