Objective: This study aimed to propose clinical guidelines for placing miniscrew implants using the results obtained from 3-dimensional analysis of maxillary anterior interdental alveolar bone by cone-beam computed tomography (CBCT). Methods: By using CBCT data from 52 adult patients (17 men and 35 women; mean age, 27.9 years), alveolar bone were measured in 3 regions: between the maxillary central incisors (U1–U1), between the maxillary central incisor and maxillary lateral incisor (U1–U2), and between the maxillary lateral incisor and the canine (U2–U3). Cortical bone thickness, labio-palatal thickness, and interdental root distance were measured at 4 mm, 6 mm, and 8 mm apical to the interdental cementoenamel junction (ICEJ). Results: The cortical bone thickness significantly increased from the U1–U1 region to the U2–U3 region (p < 0.05). The labio-palatal thickness was significantly less in the U1–U1 region (p < 0.05), and the interdental root distance was significantly less in the U1–U2 region (p < 0.05). Conclusions: The results of this study suggest that the interdental root regions U2–U3 and U1–U1 are the best sites for placing miniscrew implants into maxillary anterior alveolar bone. [Korean J Orthod 2014;44(2):54-61]