Objective: The purpose of this study was to evaluate the clinical efficacy of polymer- and rhodium-coated wires compared to uncoated wires by measuring the frictional forces using self-ligation brackets. Methods: 0.016-inch nickel titanium (NiTi) wires and 0.017 × 0.025-inch stainless steel (SS) wires were used, and the angulations between the brackets and wires were set to 0<sup>o</sup>, 5<sup>o</sup>, and 10°. Upper maxillary premolar brackets (Clippy-C<sup>?</sup>) with a 0.022-inch slot were selected for the study and a tensile test was performed with a crosshead speed of 5 mm/min. The maximum static frictional forces and kinetic frictional forces were recorded and compared. Results: The maximum static frictional forces and the kinetic frictional forces of coated wires were equal to or higher than those of the uncoated wires (p < 0.05). The maximum static frictional forces of rhodium-coated wires were significantly higher than those of polymer-coated wires when the angulations between the brackets and wires were set to (i) 5<sup>o</sup> in the 0.016-inch NiTi wires and (ii) all angulations in the 0.017 × 0.025-inch SS wires (p < 0.05). The kinetic frictional forces of rhodium-coated wires were higher than those of polymer-coated wires, except when the angulations were set to 0<sup>o</sup> in the 0.016-inch NiTi wires (p < 0.05). Conclusions: Although the frictional forces of the coated wires with regards to aesthetics were equal to or greater than those of the uncoated wires, a study under similar conditions regarding the oral cavity is needed in order to establish the clinical implications. [Korean J Orthod 2014;44(4):157-167]