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Assembly of chemically reduced graphene oxide with folic acid functionalized with pyrene moieties and electrochemical sensing of folate receptors
- 한국탄소학회
- Carbon Letters
- 제27권
- : SCOPUS, SCIE, KCI등재
- 2018.07
- 26 - 34 (9 pages)
To formulate folate receptor (FR)-specific graphene-based electrochemical electrodes, a folic acid (FA) derivative attached with two pyrene molecules on the glutamate tail of FA was synthesized. The resulting pyrene-functionalized FA (FA-Py) presented the spontaneous noncovalent binding on chemically reduced graphene oxides (rGO) through an π-π interaction. Ultrathin morphology, high water-resistance, and preservation of intact FR-specific pteroates from the rGO/FA-Py assembly allow this assembly to be exploited as robust and FR-specific electrochemical electrode materials. The limits of detecting rGO/FA-Py modified electrodes were found to be as low as 3.07 nM in FR concentrations in cyclic voltammetry analysis
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
Conflict of Interest
Acknowledgements
References