
Atorvastatin pretreatment attenuates kainic acid
induced hippocampal neuronal death via regulation of lipocalin-2- associated neuroinflammation
- Zhen Jin Yohan Jung Chin-ok Yi Jong Youl Lee Eun Ae Jeong Jung Eun Lee Ki-Jong Park Oh-Young Kwon By
- 대한생리학회-대한약리학회
- The Korean Journal of Physiology & Pharmacology
- 제22권 제3호
- 등재여부 : KCI등재
- 2018.05
- 301 - 309 (9 pages)
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase-2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
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