Diphenylhydantoin 및 수종(數種)의 중추신경계(中樞神經系)에 작용(作用)하는 약물(藥物)이 흰쥐 대뇌피질절편(大腦皮質切片)의 산소소비량(酸素消費量) 및 non-inulin space Na⁺, K⁺농도(濃度)에 미치는 영향(影響)

The Effects of Diphenylhydantoin and Several other Agents Acting on CNS on the Qo₂ and Non-inulin Space Na⁺, K⁺ Concentration in Cerebral Cortcial Slices of Rat

The effects of dephenylhydantoin, strychnine, coramine, d-amphetamine and chlorpromazine on Qo₂ and non-inulin space Na⁺, K⁺ concentration of rat cerebral cortical slices incubated in pH 7.4 glycylglycine glucose saline was investigated. In general, there are decreased non-inulin space Na⁺ concentration or increased non-inulin space K⁺ concentration or both when the ratio of respiration to non-inulin space is greater than control group except in case of chlorpromazine 10^-4 M. And it is suggested that the ratio of respiration to non-inulin space is responsible more closely for the non-inulin space Na, K concentration than Qo₂ expressed per tissue wet weight. Effects of diphenylhydantoin and several other agents on electrolytes and the electroshock seizure threshold are discussed.