The Pharmacologic action of ethanol extracts and essential substance obtained from fruits of Evodia rutaecarpa are studied. 1) Motility of the isolated rabbit-intestine was decreased in proportion to the concentration of essential substance. 2) Intestinal contraction induced by acetylcholine 10? 6g/ml was inhibited by the essential substance 10<sup>-5</sup>g/ml. 3) Contractile responses of the isolated rabbit-intestine by serotonin 10<sup>-5</sup>g/ml and histamine 10<sup>-5</sup>g/ml were depressed significantly with the essential substance 10<sup>-5</sup>g/ml. 4) Alpha adrenergic receptor blocking effect of dihydroergotamine was interfered significantly with the essential substance. 5) Analgesic effect in mice by acetic acid stimulating method was observed significantly with both of the ethanol extracts and essential substance. 6) Blood pressure and respiration of the rabbits were not significantly influenced with the essential substance.