CCl₄의 간장독작용(肝臟毒作用)에 미치는 Guanethidine과 α-Methyl-paratyrosine 의 영향(影響)

Influences of Guanethidine and α-Methyl-para-tyrosine on the hepatotoxicity of Carbon tetrachloride

In this paper, the influences of adrenergic neuronal blockades of different mode: guanethidine and α-methyl-para-tyrosine on the changes induced by carbon tetrachloride (CCl₄) of hepatic total lipid, glycogen, and lipid peroxide contents and serum lactic dehydrogenase activity were investigated in male mice. The results obtained were summarized as follows: 1) The hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were markedly increased by CCl₄, but hepatic glycogen content were decreased. 2) The hepatic total lipid and lipid peroxide contents and serum lactic dehydrogenase activity were not significantly changed by guanethidine(20mg/kg) or α-methyl-para-tyrosine (5 mg/kg) injection. 3) The increase of hepatic total lipid induced by CCl₄ was inhibited by the pretreatment of guanethidine or α-methyl-para-tyrosine, and the increase of hepatic lipid peroxide content induced by CCl₄ was slightly inhibited by them. But the decrease of hepatic glycogen content and the increase of serum lactic dehydrogenase activity induced by CCl₄ were not affected by them.