Phenotype of peroxisome proliferator-activated receptor-α(PPARα)deficient mice on mixed background fed high fat diet
Phenotype of peroxisome proliferator-activated receptor-α(PPARα)deficient mice on mixed background fed high fat diet
- 대한수의학회
- Journal of Veterinary Science
- 제4권 제3호
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2003.12239 - 244 (6 pages)
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Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-α (PPARα) on obesity. Previous reports demonstrated that PPARα is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARα-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARα-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARα-/- mice on mixed genetic background (C57BL/6N X 129/Sv) fed a high fat diet for 16 weeks. PPARα-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARα target genes encoding enzymes for fatty acid β-oxidation.
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