Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors
Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors
- Chi-Ho Yu, Du-Na Hwang, Ji-Young Yhee, Jong-Hyuk Kim, Keum-Soon Im, Whan-Gook Nho, Young-Soo Lyoo, Jung-Hyang Sur*
- 대한수의학회
- Journal of Veterinary Science
- 제10권 제1호
- 등재여부 : KCI등재
- 2009.03
- 1 - 7 (7 pages)
Primary testicular tumors are the most common causes of cancer in male dogs. Overall, the majority of canine patients should be cured by testicular surgery. However, tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs). We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.