Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from <em>Paenibacillus</em> <em>polymyxa</em> JB115
Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from <em>Paenibacillus</em> <em>polymyxa</em> JB115
- Eun-Ju Ko, Yun-Young Byon, Youngheun Jee, Taekyun Shin, Seung-Chun Park, Tae-Wook Hahn, Hong-Gu Joo
- 대한수의학회
- Journal of Veterinary Science
- 제12권 제2호
- 등재여부 : KCI등재
- 2011.06
- 187 - 190 (4 pages)
We investigated the immunostimulatory effects of a novel β-glucan purified from <em>Paenibacillus</em> (<em>P</em>.) <em>polymyxa</em> JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from <em>P. polymyxa</em> JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.