커버이미지 없음
KCI등재
학술저널
SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
SRY-positive 78, XY ovotesticular disorder of sex development in a wolf cloned by nuclear transfer
- Jung Taek Kang, Hyung Jin Kim, Hyun Ju Oh, So Gun Hong, Jung Eun Park, Min Jung Kim, Min Kyu Kim, Goo Jang, Dae Yong Kim, Byeong
- 대한수의학회
- Journal of Veterinary Science
- 제13권 제2호
- 등재여부 : KCI등재
- 2012.06
- 211 - 213 (3 pages)
Recently, we reported the three wolves cloning with normal karyotype from somatic cells of endangered male gray wolves (Canis lupus), but one wolf had female external genitalia. In this study, we conducted further clinical, histological, and genetic analyses. This cloned wolf had a normal uterus but developed ovotestis. Through molecular analysis of the SRY gene, a mutation in the coding sequence of SRY gene could be excluded as a cause of intersexuality. This is the first report of a cloned wolf with a 78, XY ovotesticular disorder affecting sexual development characterized by bilateral ovotestes.