비 지질 산화손상에 대한 어성초 뿌리의 항산화 효과

This study was designed to evaluate the antioxidative effects of Houttuynia cordata root on nonlipid oxidative damage. The antioxidative effects of methanolic (MeOH) extract of Houttuynia cordata root on non-lipid, including liposome oxidation, oxidation of deoxyribose, protein oxidation, chelating, scavenging, and 2`-deoxyguanosine (2`dG) oxidation were investigated. Houttuynia cordata root exhibited high antioxidative effect in a liposome model system. The inhibitory effect of MeOH extract on deoxyribose damage exhibited antioxidative effect and it afforded considerable protection against damage to deoxyribose. In addition, MeOH extract at over 300 μg was effective (> 80%) in protecting protein oxidation. The MeOH extracts exhibited metal binding ability for hydrogen peroxide. Furthermore, the oxidation of 2`dG to 8- hydroxy-2-deoxyguanosine was inhibited by MeOH extracts, and scavenging activity for hydroxyl radical exhibited a remarkable effect. The present results on biological model systems showed that MeOH extracts was effective in the protection of non-lipids against various oxidative model systems.