Dehydroepiandrosterone and cortisol concentrations in the cerebrospinal fluid of dogs
- Paolo Mongillo , Marco Bernardini , Elisa Prana , Federica Balducci , Gianfranco Gabai , Lieta Marinelli
- 대한수의학회
- Korean Journal of Veterinary Research(구 대한수의학회지)
- 제57권 제1호
- 등재여부 : KCI등재
- 2017.03
- 47 - 50 (4 pages)
Concentrations of cortisol, dehydroepiandrosterone and dehydroepiandrosterone-sulfate were measured by performing radioimmunoassay of the cerebrospinal fluid of 68 dogs diagnosed with idiopathic epilepsy or inflammatory, degenerative, or non-neurological disease. No steroid concentration differences were found among diagnoses. Dehydroepiandrosterone and dehydroepiandrosterone-sulfate concentrations were higher in males than in females and dehydroepiandrosterone-sulfate decreased with increasing age. No sex or age effects were observed on cortisol or hormone ratios. Although limited to a relatively small sample, our results show sex- and age-dependent variations in these neurosteroid concentrations in cerebrospinal fluid. The role of such variations in the pathophysiology of the dog brain warrants further investigation.