Purpose: This study attempted to examine nursing students’ self-esteem, interpersonal relationships, and self-efficacy, to identify factors affecting empathy. Methods: A predictive correlational design was used. The participants in this study were nursing students from fours university of Korea. The questionnaires were administered to a convenience sample of 147 nursing students in the Republic of Korea. Results: Mean item scores for self-esteem, interpersonal relationship, self-efficacy, and empathy were 3.83, 3.63, 3.30, and 3.44, respectively (possible range, 1–5). Empathy was correlated with self-esteem, interpersonal relationships, and self-efficacy. The multiple regression analysis revealed that 45.9% of the variance in empathy is attributable to gender, major satisfaction, self-esteem, self-efficacy, and interpersonal relationships. The most important factor interpersonal relationship explained. Conclusion: Improving nursing students’ major satisfaction, self-esteem, self-efficacy, and interpersonal relationships are strategies that may foster empathy.
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