비글견의 치조골 결손부에 이식한 2가지 종류의 BMP 함유 골이식재의 치유 비교

Comparison of healing of two types of BMP-containing bone graft materials grafted in alveolar defects of beagle dogs

Purpose: To explore the histologic healing process by transplanting two types of bone graft materials, which are equipped with rhBMP-2, into the alveolar bone defect of the beagle dogs. Materials and Methods: First and third premolars of two 2-year-old beagle dogs were extracted, artificially forming alveolar bone defect. O-BMP (Osstem Implant Co. Busan, Korea) and Cowell BMP (Cowellmed Co. Busan, Korea) were grafted in each alveolar bone defect of each beagles, One was sacrificed after four weeks, and the other was sacrificed after eight weeks, observing the tissue healing of the bone grated. Results: In the beagle dog, which was sacrificed four weeks later, the rate of new bone formation in the O-BMP grafted site was observed at 43.87%, which was greater than 40.72%, the rate of new bone formation in Cowell BMP grafted site. Eight weeks later, the new bone formation rate observed in the remaining dog was 59.56% in O-BMP grafted site and 56.35% in Cowell BMP grafted site. Conclusions: O-BMP and Cowell BMP, which contain rhBMP-2, were transplanted into the extraction socket and displayed good bone formation. It is thought to be useful for ridge preservation and guided bone regeneration.