
BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
- Hee-Ju Kang Kyung-Yeol Bae Sung-Wan Kim Il-Seon Shin Young Joon Hong Young-keun Ahn Myung Ho Jeong J
- 대한신경정신의학회
- Psychiatry Investigation
- 제15권 제11호
- 등재여부 : KCI등재
- 2018.11
- 1094 - 1097 (4 pages)
Objective Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. Methods In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Åsberg Depression Rating Scale and covariates potentially affecting SI were estimated. Results Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni’s correction. Conclusion These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.
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