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KCI등재 학술저널

일주기리듬의 조절이상이 양극성장애의 핵심 발병 기전일까?

Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?

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Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors’ own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.

서론

일주기리듬과 기전

위상반응곡선(Phase Response Curve)

양극성장애에서 일주기리듬의 변동

환경적 요인

일주기리듬의 어긋남(Circadian Misalignment)

양극성장애와 주요우울장애

장극성장애의 예후와 일주기리듬

일주기리듬의 치료적 적용

결론