Primary Adenocarcinoma with Mixed Colonic, Mucinous and Signet Ring Cell Differentiation of Urinary Bladder

Primary Adenocarcinoma with Mixed Colonic, Mucinous and Signet Ring Cell Differentiation of Urinary Bladder

Primary adenocarcinoma is a rare neoplasm of the urinary bladder, constituting approximately 2.5% of all primary bladder malignancies. Signet ring cell variant is even rarer, constituting approximately 0.5% to 2.0% of all primary carcinoma of the urinary bladder. However, glandular differentiation in the urinary bladder is relatively more common than primary adenocarcinoma of the urinary bladder. Therefore, diagnosis of primary adenocarcinoma of the urinary bladder can be very challenging, but of significant clinical importance. We report on a case of adenocarcinoma with mucinous and signet ring cell differentiation in the bladder dome in a 49-year-old female.