강직성 척추염 환자에서 설파살라진에 의해 유발된 말초 혈액과 흉수의 호산구증

Sulfasalazine-induced Peripheral and Pleural Fluid Eosinophilia in Patient with Ankylosing Spondylitis

Ankylosing spondylitis (AS) is an inflammatory joint disease affecting the axial skeleton, peripheral joints, entheses, and extra-articular site. Non-steroidal anti-inflammatory agents are the first line drugs for treatment of AS. Sulfasalazine is regarded as the second line drug and is usually used on AS patients with concomitant peripheral arthritis. Sulfasalazine has side effects, including liver toxicity, hematological abnormality, skin eruption, and other symptoms. However, eosinophilic pleural effusion is rare. Thus, we report on a patient with peripheral eosinophilia and eosinophilic pleural effusion after taking sulfasalazine for treatment of AS.