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The Effects of Ulinastatin against the Development of Neuropathic Pain Is Involved with Changing the Levels of IL-6, not IL-10

The Effects of Ulinastatin against the Development of Neuropathic Pain Is Involved with Changing the Levels of IL-6, not IL-10

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Background: We evaluated the effect of ulinastatin on paw withdrawal threshold (PWT), IL-6, and IL-10 in SD rats after spinal nerve ligation (SNL). Methods: Group C received N/S and Group E received ulinastatin IV for three days following SNL. PWT, IL-6, and IL-10 were measured on the 3<sup>rd</sup>, 5<sup>th</sup>, and 7<sup>th</sup> day. Results: Group E showed higher PWT compared to group C. IL-6 was lower in group E than in group C. No differences in IL-10 were observed between group C and group E. Conclusion: Ulinastatin increased the PWT and its effect appears to be involved with IL-6, not IL-10.

Introduction

Materials and Methods

Results

Discussion

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