기관지 천식환자에서 기관지 확장제 사용법에 따른 폐기능과 안전성

Pulmonary Function and Safety according to the Methods of Bronchodilator Use among Patients with Bronchial Asthma

Purposes: This study was aimed to examine the effect of usage and preparation for bronchodilators on lung function and safety among patients with bronchial asthma. Method: A total of seven adult asthma patients were recruited from a University hospital located in K City in Korea. The participants took inhaled medication by a nebulizer with two different methods: (1) mixing pratropium bromide with salbutamol, (2) separate delivery of ipratropium bromide and salbutamol. The participants performed lung function testing before and after a nebulized treatment. Prepared brochodilators were kept either in room air or under refrigeration through the 1st to 30th days. Results: Pre and post forced expiratory volume at one second (FEV1) of the predicted value were 44.86% and 46.57%, and variance was 4.73% in the mixed method. Pre and post predicted FEV1 were 43.57% and 46.37%, variance was 7.67% in the separate method. There was no statistically significant difference between two methods of nebulized bronchodilator (p=.482). There was no evidence of bacterial growth on both of room air and refrigeration through the time. Conclusion: This study suggests further investigation, given the limitations in this study in which participants were very severe asthmatic patients and sample size was small.