당귀(Angelica spp.)의 기원분석에 관한 분자생물학적 연구 현황 및 향후과제
Current status on the development of molecular markers for differentiation of the origin of Angelica spp.
- 이신우(Shin-woo Lee) 이수진(Soo-jin Lee) 한은희(Eun-heui Han) 신의철(Eui-cheol Sin) 조계만(Kye Man Cho) 김윤희(Yun-hee Kim)
- Journal of Plant Biotechnology
- 44권 1호
- 등재여부 : KCI등재
- 12 - 18 (7 pages)
The dried root of Angelica species is used in traditional Chinese medicine in East Asia, particularly in Korea, China and Japan. Since the plant origin differs in these countries, they are often misused or adulterated in the commercial markets, resulting in distrust among the consumers. Enormous efforts have therefore been focused to distinguish the origin for the Angelica genus, by using morphological or cytogenetical analyses, and chemical markers based on biochemical analyses of secondary metabolites. DNA is considerably stable against different cultivation conditions, and to treatment and processing after harvesting of plants. Hence, several researches have been filed for the development of molecular markers, based on the single nucleotide polymorphisms in specific regions of DNA. However, there are several obstacles for application in the commercial markets, concerning the reproducibility, accuracy, sensitivity, and rapidity of these tests. In this review, we summarize the research achievements that help classify the origin of Angelica species, in particular, Angelica gigas Nakai. A. sinensis(oliv.) Diels, A. acutiloba Kitag., and A. acutiloba var. sugiyamae Hikino. Further researches are required for practical applications.
문제점 및 향후 과제