A Case of Dapsone Hypersensitivity Syndrome
- 조선대학교 의학연구원
- The Medical Journal of Chosun University
- 제34권 제2호
- 2009.06
- 117 - 121 (5 pages)
Dapsone (4,4,-diamino-diphenyl sulfone), a potent anti-inflammatory and antiparasitic compound, is still used as a first line drug for leprosy. In Europe and the United states of America, however, it finds application mainly in the treatment of bullous dermatoses and dermatitis herpetiformis. The most frequent side effects are dose-related methemoglobinemia and hemolytic anemia, and rarely, it can cause an idiosyncratic reaction, called dapsone hypersensitivity syndrome (DHS). The authors report a case of dapsone hypersensitivity syndrome occurring in a 21-year-old female diagnosed by the presentation of systemic erythemat papuloplques, hepatosplenomegaly, acute hepatitis, lymphadenopathy, and mild pericardial effusion with 3 weeks intake of dapsone for the treatement of acne that showed rapid improvement of symptoms after cessation of the drug and application of systemic steroids.
Introduction
Case report
Discussion
Conclusion