방광의 요로상피암종에서 p27，p53，p73 단백 발현에 대한 연구

Expression of p27, p53, p73 protein in Urothelial Carcinoma of the Urinary Bladder

The Aim of this study was to investigate the expression of p27, p53 and p73 proteins in urothelial carcinomas of the urinary bladder, and to evaluate the relationship between pathologic parameters and each protein expression level. The expression of p27, p53 and p73 proteins were studied in 21 urothelial carcinoma, high glade, 12 urothelial carcinoma, low glade, 7 urothelial carcinoma in situ, 9 cystitis cystica and 9 chronic cystitis by immunᄋhistochemistry, The positive expression of the p27, p53 and p73 protein was significantly associated with high grade and stromal invasion. Our data suggest that p27, p53 and p73 protein may be involved in the development and progression of urothelial carcinoma. In addition, p53 may be a 니seful prognostic marker for individual urothelial carcinoma patients.