갑상샘 유두상 암종에서 CD56과 p63 단백 발현

Expression of CD56 and p63 in the papillary carcinoma of the Thyroid

Papillary carcinoma of the thyroid (PTC) is the commonest thyroid cancer. Diagnosis of papillary thyroid carcinoma, in many but not all cases, is an easily achievable diagnosis with almost minimal interobservable variability between pathologists. However since the introduction of follicular variant of PTC and the wide threshold range in interpretation of the clearly set pathological criteria for diagnosis of PTC, between pathologists including experts, the diagnosis in some cases became quite difficult. Unfortunately some cases are unjustifiably over-called as follicular variant of PTC as result of the wide inter observable variability between pathologists. CD56 is a neural cell adhesion molecule, hence its expression may affect the migratory capacity of tumor cells. The tumor suppressor protein p53 has recently been shown to belong to a family that includes two structurally related proteins, p63 and p73. Expression of p63, a transcription factor that is transcribed into six isoforms, is important for the regulation of normal development. In this study, we assessed the protein expression and loss using antibodies against CD56 and p63 in normal follicular thyroid neoplasms in an attempt to evaluate its diagnostic value. A total 109 cases were studied with tissues from 49 carcinoma (33 classic papillary carcinoma, 16 follicular variants of papillary carcinoma), 15 follicular adenoma, 17 nodular hyperplasia, 17 lymphocytic thyroiditis and 11 normal thyroid evaluated by immunohistochemistry for the expression of this marker. Our results showed CD56 positive in all the lesions and adenomas except for PTC. CD56 was negative in all PTC cases. p63 showed selective focal positivity in PTC cases, in contrast to other non PTC lesions/ tumors. p63 expression was in 25 out of 33 cases of PTC and was consistently absent in all the non PTC cases. Our aim was to study the applicability of difference in CD56, p63 expression as a marker that distinguishes PTC, including the follicular variant from other We concluded that a panel consisted of CD56 and p63 is of value in distinction of PTC from other thyroid follicular lesion. p63 is a specific but less sensitive marker for PTC than CD56. CD56 is more specific and sensitive marker than p63, however it is a negative rather then a positive marker for PTC.