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생균제(probiotics)의 이해와 작용기전

Understandings and Mechanisms of Probiotics

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Probiotics are defined as nonpathogenic living microorganisms, including some commensal bacterial flora, which have beneficial effects on host health and disease prevention and/or treatment. They have shown beneficial effects of probiotics on several human diseases, such as antibiotic-associated diarrhea and acute infectious diarrhea, irritable bowel syndrome and atopic dermatitis in children. Most commonly employed probiotics were Lactobacillus GG, Bifidobacterium spp., Streptococcus spp., and the yeast Saccharomyces boulardii. Studies discussed in this review suggest 3 distinct cellular and molecular mechanisms for probiotic regulation : 1) Probiotics block pathogenic bacterial effects by producing bactericidal substances and competing with pathogens and toxins for adherence to the intestinal epithelium; 2) Probiotics regulate immune responses by enhancing the innate immunity and modulating pathogen-induced inflammation via toll-like receptor-regulated signaling pathways; and 3) Probiotics regulate intestinal epithelial homeostasis by promoting intestinal epithelial cell survival, enhancing barrier function, and stimulating protective responses. Significant adverse effects are rare, and there are no known interactions with medications.

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생균제 (Probiotics) 란?

생균제의 작용 기전

생균제의 분류와 특성

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