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학술저널

Design of Pro-rich Model Antimicrobial Peptides with Improved Bacterial Selectivity

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To develop novel Pro-rich model antimicrobial peptides with shorter length and higher bacterial selectivity/ therapeutic index than a natural Trp/Prᄋ-rich antimicrobial peptide, indolicidin, we synthesized three Prorich model antimicrobial peptides composed of Trp, Lys, Leu and Pro resides. Compared to natural indolicidin, the designed Pro-rich model peptides had approximate 6- to 11 -fold higher bacterial selectivity/ therapeutic index. These designed peptides selectively bind to negatively charged liposomes [L-aphosphatidylethanolamine (EYPE) / L-a-phosphatidyl DL-glycerol (EYPG) (7:3, w /w)],mimicking bacterial membranes. This result indicated that the high bacterial selectivity of designed Pro-rich model peptides may due to their selective interaction with negatively charged phospholipids. Taken together, our designed peptides appear to be excellent candidates for future development as a novel antimicrobial agent.

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