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학술저널

후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의

The Significance of Expression of Galectin-1 and -7 in Squamous Cell Carcinomas of the Larynx

Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007,were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -1 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.

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