The purpose of this study was to investigate the differences in the perception of Home Economics between female and male among high school students who have learned Home Economics and who have never learned. The number of 400 samples were analyzed with frequencies, percentages, t-tests, regressions and x? analyses by SPSS/Win. The results showed that the male students who have taken Home Economics were more likely than those who have never taken perceived Home Economics as a living science and to be interested in the subject. There were sexual differences among high school students who have learned the subject in favorite units, increases in interests, satisfaction with the contents, etc. Sex and the level of participating household works were the most influential factors on the perception of the subject of high school students.