아미노산 분유로 변경 후 병증이 호전되어 우유 단백 유발 알러지로 진단된 신생아 4예

Four cases of newborns diagnosed with cow’s milk protein allergy after changing to amino acid-based formula

Cow’s milk protein allergy(CMPA) or cow’s milk protein-induced allergy is the most common food allergy in children. It has been reported to have a 2 to 3% prevalence in infants within one year of age, but the exact prevalence in newborns within one month of age has not yet been accurately reported. In children who have non-specific symptoms such as diarrhea, bloody stool, vomiting, and urticaria within a few weeks of exposure to milk protein, if the symptoms improve when changing to a diet without milk protein, a milk allergy can be diagnosed without additional tests. The extensively hydrolyzed formula is generally recommended first as a diet with milk protein eliminated, but amino acid-based formula can be considered preferentially as milk allergy may recur due to residual immunologically active proteins in the extensively hydrolyzed formula. In this report, the authors report four cases of newborns diagnosed with CMPA after changing to amino acid-based formula.