감 추출물이 아토피 피부염 관련 사이토카인 분비에 미치는 효과

Effect of Diospyros kaki extracts on atopic dermatitis-related cytokines

Diospyros kaki, also known as persimmon, has been used in traditional medicine for its potential health benefits. In this study, we employed 1,3-butylene glycol extract (DBG) and ethanol extract (DET) to investigate their anti-atopic dermati-tis (AD) activity. The results showed that DBG and DET were effective in reducing AD-related cytokines such as IL-8, TNF-α, and immunoglobulin E. Additionally, DBG and DET both upregulated the Th1 cytokine, IL-2. Furthermore, both extracts exhibited significant superoxide dismutase-like activities. These findings collectively suggest that D. kaki ex-tracts may be beneficial in improving AD due to their immunomodulatory and antioxidant properties.