Purpose: This is a descriptive research study to identify the change in the quality of life according to the restriction of activity in patients with chronic degenerative musculoskeletal disease. Methods: Based on the data of the 8th Korea National Health and Nutrition Examination Survey (KNHANES), the general and disease characteristics of the subjects were analyzed using frequency analysis, descriptive statistics, and quality of life according to restriction of activity were ana-lyzed by logistic regression on the SAS 9.4 program. Results: The results of the analysis showed that the quality of life in patients with chronic degenerative musculoskeletal disease was lower when there was activity restriction, which had a significant effect on mobility (B=1.437, OR 4.207[2.116, 8.364], <.001) and selfcare (B=1.541, OR 4.670[2.466, 8.843], <.001), and disrupted usual activities (B=1.691, OR 5.428[2.782-10.592], <.001). Pain/inconvenience (B=1.937, OR 6.943[3.776, 12.764], <.001) and anxiety/depression (B=.946, OR 2.576[1.380, 4.812], =.003) increased when there was activity restriction. Conclusion: Thus, activity limitations can have a major impact on the quality of life. Hence, efforts should be made to pay attention to the aspects of the health care system that can effectively prevent and manage os-teoarthritis and osteoporosis and reflect them politically.
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