Purpose: This study sought to investigate the factors that influence the implementation of evidence-based practice by clinical nurses working at a tertiary hospital. Method: The study was a based on descriptive survey research design. All the participants were nurses working at a tertiary hospital in the D region. The collected data were analyzed using de-scriptive statistics, the t-test, ANOVA, Pearson’s correlation coefficient, and multiple regression analysis with the SPSS sta-tistics 22.0 program. Results: The results of the regression analysis showed that the factors influencing evidence-based practice implementation were patient-centered nursing (β=.16, p=.004), organizational culture for evidence-based practice (β=.14, p=.009), and a knowledge of evidence-based practice (β=.53, p<.001). The explanatory power of these varia-bles was 47.2% (F=21.53, p<.001). Conclusion: For clinical nurses to carry out evidence-based practice, it is essential that they first understand this practice well. Therefore, education on evidence-based practice must continue, and organ-izational efforts to support this are needed. Additionally, to implement evidence-based practice, individualized nursing services that consider the patient’s needs must be provided.
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