자율신경균형 증진 간호중재를 위한 생행동적 이론적 기틀 구축: 세포노화 기전 기반으로

A biobehavioral theoretical framework based on the mechanism of cellular aging for nursing interventions to promote autonomic balance

Purpose: This study reviewed the pathophysiological mechanisms of cellular aging caused by psycho-logical stress and aimed to establish a biobehavioral theoretical framework for nursing interventions to promote autonomic balance based on these mechanisms. Methods: A comprehensive literature re-view was conducted. Results: A review of the literature showed that the stress response increases the secretion of catecholamines and glucocorticoids, resulting in a greater allostatic load. This load induc-es inflammatory reactions and oxidative stress, shortening telomere length and damaging mitochon-drial DNA, which can lead to cellular aging. Based on this mechanism, a biobehavioral theoretical framework for nursing interventions was established. This framework focuses on delaying or inhibiting the cellular aging process by acting on the stress response stage and improving autonomic balance. Conclusion: According to the proposed biobehavioral theoretical framework, stress-relieving nursing interventions may act on the mechanism of cellular aging caused by stress responses. We believe that this framework could expand our understanding of the biobehavioral aspects of stress and would fa-cilitate efforts to use biomarkers to evaluate the effectiveness of stress-related nursing interventions at the cellular level.