Purpose: This study aimed to assess the levels of Health-Related Quality of Life (HRQoL) and the related factors among adults in multicultural households in South Korea and to develop health policies. Methods: Data from 150 respondents aged 19 years and above from the 2020 Korea Health Panel Survey were analyzed using SPSS/WIN 25 for descriptive statistics, the independent t-test, ANOVA, and multiple regression. Results: The degree of HRQoL of adults in multicultural households was low. HRQoL differed significantly depending on age, education, economic activity, alcohol drinking, chronic disease, self-rated health status, and bedridden. HRQoL was lower in those aged 60 years and above, with low education levels, who were not economically active, were non-drinkers, were suffering from a chronic disease, or were bedridden. Significant predictors of HRQoL included age, economic activity, alcohol drinking, and self-rated health status, and explained 48.6% of the variance. The sex, spouse, medical insurance type, unmet healthcare needs, smoking, regular exercise, body mass index, disability, stress, depression, anxiety, and suicidal ideation did not significantly impact HRQoL. Conclusion: The HRQoL of adults in multicultural households in South Korea is low and is influenced by demographics, health behavior, and physical health factors. These findings should be considered during the preperation of effective multicultural policies.
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