Purpose: This study was conducted to evaluate the effectiveness of a human rights education program based on multicultural understanding, developed for nursing students participating in mental health nursing practice. Methods: A quasi-experimental study with a non-equivalent control group pre-post design was employed. The participants included 35 students in the experimental group and 29 in the control group who participated in mental health nursing practice during the study period after obtaining research ethics approval. The multicultural human rights education program was provided over four sessions, totaling six hours, with each session lasting 90 minutes and held twice a week for two weeks. Data were analyzed using descriptive statistics, percentages, and t-tests with SPSS WIN 22.0. Results: Compared to the control group, the experimental group that received the multicultural human rights education program showed statistically significant improvements in overall multicultural acceptance (t=2.23, p=.029), and the sub-factors related to national identity (t=2.657, p=.012), stereotypes and discrimination (t=3.417, p=.001) within the diversity domain. Conclusion: The program emphasized that individuals can belong to different cultures, and that culture does not exist in isolation, but is dynamic and formed through interaction. The human rights education program based on an understanding of multiple cultures was found to enhance the acceptance of different cultures among nursing students. It is expected that this program will contribute to strengthening the mental health nursing competencies of future nurses working with individuals from diverse backgrounds. Further application of this program within the nursing curriculum, along with its refinement and expansion, is recommended.
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